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. The Mn^sup 2+^ and Ca^sup 2+^ concentrations used were 5 mM in all the experiments unless specified otherwise
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. In addition to the asphericity, we computed ensemble-averaged shape parameters (S) for each protein sequence
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. The pentapeptide GGAGG has P^sub II^ conformation
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. 0) will dissociate TTR into unfolded monomers (Lai et al
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. Upon maturation the oligomers clustered into either protofibrils or spherical aggregates, and upon further maturation the spheres shrink in size as fibrils extend in length
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. This may have been due to rapid resorption of unfertilized oocytes or an artifact of the fragile nature of fertilized ovaries, which made it difficult to obtain representative histological preparations
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. ©2005 British Editorial Society of Bone and Joint Surgerydoi:10
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. These hierarchical distance distributions reflect the so-called dilatation symmetry in the EV limit whereby contact density maps for one protein sequence can be rescaled to obtain the contact density map for another sequence
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. When effectors were added, the final concentrations were 5 mM MgCl^sub 2^ and 2
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. Inspection of the EIC^sup sc^ (Fig
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.RESULTS AND DISCUSSIONCharacterization of soluble prefibrillar aggregates and protofibrilsGeneration of prefibrillar oligomers of TTR from the A-stateProlonged dialysis of TTR (96 h, 4°C) versus 10 m M HCl in dH^sub 2^O in the absence of salt (pH 2
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