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The hydrodynamic radii (R^sub h^) for denatured proteins scale with chain length (N) as: R^sub h^ = 2
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Contrary to interpretations of many such experiments, numerous molecular simulations (7,23,99) and recent single-molecule experiments (75) provide little evidence of long-range residual structure under harshly denaturing conditions
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DmAChE, for example, hydrolyses its natural substrate (turnover number ~1000 s^sup -1^) 50% faster than HuBChE ((31) and references therein)
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Its apparent overall correlation time is ~10 ns at 308 K, as expected for a highly dynamic complex of this shape and size
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6 and Table 2), which was also recently reported from TTR aggregation measurements by the Kelly group (Hurshman et al
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, K^sub d^(app) ~ 7 nM) previously determined by FRET (Runnels and Scarlata, 1998)
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Pressure would be expected to stabilize the specific interactions that occur between PH-PLCδ^sub 1^ and PI(4,5)P^sub 2^ although enhancement of binding under pressure has not been observed (Rebecchi et al
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Among the Piloto positive stations (n=20), P
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Radiation from nearby stars heats up molecular bonds in the cloud, breaking them apart and liberating atomic hydrogen
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Role of secondary structure elements in tertiary foldingThe systematic study of hairpin ribozyme constructs containing different combinations of helical junction and loop elements presented here enables us to define the role of these secondary structural elements during tertiary folding
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