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Molten globule monomers have been proposed as intermediates in the dissociation of some dimeric proteins, including human superoxide dismutase (Silva et al
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Some additional explanation is here requisite which I cannot give
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A twofold advantage underlies our choice of sort-core repulsions
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This is mainly because of the short spatial range of EV interactions
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EI^sup sc^ self-associates, as other El proteins do (2-4); 2)
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Morimoto; unpublished data; March 2006) and mice treated with the VEGF inhibitor SU5416 (unpublished observation)
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5 the protein conformation undergoes a reversible transition which leads to a swelling of the monomeric unit (29,30)
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DCVJ responds to early species, i
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For instance, we have shown recently that, under certain conditions, the in vitro amyloidogenesis of insulin closely mimics certain aspects of the strain behavior of prion propagation (Dzwolak et al
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, the ingredient subcords are of equal length and are evenly aligned
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Even small (~100 residue) proteins have a configurational space dimensionality of several hundred (think of the bond angles along the polypeptide main chain alone)
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The rate-determining "gutter" dimensions lie orthogonal to other "zipper" dimensions describing the local formation of secondary structure, that are characterized by a continuous folding funnel
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Single-molecule fluorescence methods for the study of nucleic acids
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No bones are apparent on the surface, nor were any revealed by digital x-ray
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