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. Similarly to that observed for EIC^sup ec^, the electrostatic, as well as the van der Waals interactions, were decreased in EIC^sup sc^, losing several salt bridges and hydrogen bonds when compared with the structure of EIC^sup tt^
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. Although there were changes in the tertiary structure, EI^sup sc^ retained some, if not all, of its secondary structure, as shown by the increase (in absolute value) of the [Θ] at 222 nm (Fig
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